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. 2021 Jan 11;22(2):665. doi: 10.3390/ijms22020665

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparative efficacy of HA-Lipo-DIC/DEX and free drugs for arthritis therapy. Arthritis was induced in C57BL/6 mice by subcutaneous injection of FCA as described in Materials and Methods. At the time of appearance of signs of arthritis (disease onset), mice were randomized (n = 5 per group) and given an intraarticular injection single dose from day eight of the following preparations: FCA only, free DIC, free DEX, or HA-Lipo-DIC/DEX. The opposite paw was served as the reference for comparison with other groups. (^★ indicates p < 0.05, ^★★ indicates p < 0.01, one-way ANOVA). Abbreviations: FCA, Freund’s Complete Adjuvant; HA, hyaluronic acid; Lipo, liposomal; DIC, diclofenac; DEX, dexamethasone.