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. 2021 Jan 11;22(2):665. doi: 10.3390/ijms22020665

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The schematic diagram of HA-Lipo-DIC/DEX structure. Liposomal nanoparticle Lipo-DIC/DEX containing both hydrophilic/hydrophobic DEX and DIC was first prepared. The preparation procedure was as described previously. HA-Lipo-DIC/DEX was prepared by mixing equal volume of liquefied HA (20 mg/mL) and Lipo-DIC/DEX as described in Materials and Methods Section. Liposomal nanoparticle structure was originally obtained from the website: https://www.slideshare.net/SunealSaini/liposomes-47868772 and modified by author. The final liquefied HA concentration was determined as 10 mg/mL.