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. 2021 Jan 12;26(2):358. doi: 10.3390/molecules26020358

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differential binding site of steroids derivatives to T. cruzi and human G6PDH. (A) Catalytic model of TcG6PDH (left side) and (B) HsG6PDH (right side), NADP⁺ and G6P are shown as orange sticks. Steroid derivatives (cyan balls and sticks). The element containing the tyrosine residue (Y295 and Y249 in Tc- and Hs-G6PDH) is shown as cartoons and olive colored sticks. The N-terminal Rossmann-fold and the C-terminal dimerization domain of TcG6PDH are shown as having their surfaces colored in light-gray and wheat color, respectively.