Table 1.

Inhibition of G6PDH by (dehydro)epiandrosterone derivatives.

	IC50 (µM)
Compound	T. cruzi	H. sapiens	Selectivity Index b
EA	3.0 ± 0.4 c	9.4 ± 1.0 a	3
1	0.053 ± 0.002	20.8 ± 4.4 a	392
2	0.11 ± 0.02	>100	>909
3	1.5 ± 0.2	>100	>67
DHEA	21.5 ± 0.5 d	11.3 ± 2.2 a	0.5
4	3.3 ± 0.7	48.0 ± 2.6	14
5	0.079 ± 0.01	>100	>1266
6	>50	>100	>2
7	>50	15.8 ± 3.3 a	0.32
Conessine	>100	>100	ND

^a IC₅₀ values reported in [27]; ^b selectivity index calculated as IC₅₀ for human G6PDH vs. IC₅₀ for T. cruzi G6PDH; Data reported in ^c [33] or ^d in [14].