Figure 4.

Function and half-life of rC1-INH without terminal galactoses. The association rate constants k_on (M⁻¹s⁻¹) for the inhibition of C1s (A), Kallikrein (B), Plasmin (C) and (D) FXIa by pdC1-INH, rC1-INH and rC1-INH RCA FT were determined. Values are means ± SD of three independent experiments, each performed in duplicate. No significant differences were observed. (E) The half-lives of pdC1-INH (n = 2), rC1-INH (n = 3) and rC1-INH RCA FT (n = 2) show that the half-lives of pdC1-INH and rC1-INH RCA FT are similar, while the half-life of rC1-INH is clearly reduced.