Figure 2.

Metabolites identified in urine with UGS and UGS-associated SCC that were not present in urine of healthy individuals [65]. The metabolites were divided in three groups: catechol estrogen-like (green), catechol-estrogen-DNA adducts (red) and 8-oxodG derivatives (blue). The catechol estrogen-DNA adducts may be a consequence of interaction of catechol estrogen derivatives with host DNA. On other hand, 8-oxodG derivatives may be a result of liberation of nitrogenous bases from DNA and/or its oxidation.