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. 2021 Jan 11;11(1):39. doi: 10.3390/life11010039

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interactions between low-density lipoproteins (LDL), oxidized LDL (ox)-LDL and platelets. LDL oxidation is assisted by reactive oxygen species (ROS). Ox-LDL bind to resting platelets by cluster of differentiation 36 (CD36), leading to platelet activation and expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX1) on platelets. Ox-LDL bind to activated platelets by LOX-1. As a result, activated platelets produce ROS, which results in a vicious circle of LDL oxidation and platelet activation.