Figure 3.

The modelling workflow in biomedicine: during model derivation, the biological knowledge and hypotheses about the studied system are encoded in a mathematical model. In model calibration, quantitative experimental data are added to characterize the mathematical model and to give values to the model parameters. In model validation, the ability of the model to make predictions is assessed by judging the agreement between new quantitative data and equivalent simulations of the calibrated model. In model analysis, a validated model is used to investigate the system using computer simulations or other tools like stability analysis.