Table 3.

Summary of current nano-mixture toxicity data for D. rerio.

No.	Article	Nanomaterials	Mixed Substance	Mixed Substance Type	Toxicity Test Guideline	Toxicity Endpoint	Mixture Toxicity Models
1	Azevedo Costa et al., 2012 Comparative Biochemistry and Physiology, Part C [176]	C60 fullerenes	As3+	Metal ions	None	Cell viability, Mitochondrial dehydrogenase functionality, Oxidative stress, Bioaccumulation	None
2	Fang et al., 2015 Journal of Hazardous Materials [160]	TiO2 NPs	Pentachlorophenol	Organic compounds	None	Bioaccumulation, Oxidative stress, Gene expression, Glutathione level	None
3	Ferreira et al., 2014 Aquatic Toxicology [131]	C60 fullerenes	Benzo[a]pyrene	Organic compounds	None	Cell viability, Oxidative stress, Bioaccumulation, Glutathione level	None
4	Ginzburg et al., 2018 ACS Nano [52]	Au NPs	Polysorbate 20	Organic compounds	None	Mortality	None
5	Henry et al., 2007 Environmental Health Perspectives [56]	C60 fullerenes	Tetrahydrofuran	Organic compounds	None	Mortality, Gene expression	None
6	Henry et al., 2013 Environmental Science & Technology [36]	C60 fullerenes	Hg+	Metal ions	Plymouth University	Mortality, Bioaccumulation, Gene expression	None
7	Hu et al., 2011 Environmental Pollution [38]	TiO2 NPs	Cd2+	Metal ions	None	Bioaccumulation	None
8	Hua et al., 2016 NanoImpact [74]	TiO2 NPs	ZnO NPs	Nano-oxide	OECD 157	Mortality	RA and CA
9	Krysanov & Demidova, 2012 Doklady Biological Sciences [146]	CeO2 NPs	Doxorubicin	Organic compounds	None	Malformations, Hatching rate	None
10	Miao, 2015 Aquatic Toxicology [119]	TiO2 NPs	Pb2+	Metal ions	None	Gene expression, Locomotion activity, Thyroid hormone content, Bioaccumulation	None
11	Park et al., 2011 Nanotoxicolog y [190]	C60 fullerenes	17α-Ethinyl-estradiol	Organic compounds	None	Bioaccumulation, Gene expression	None
12	Park et al., 2015 Molecular & Cellular Toxicology [60]	Ag NPs	Ag nanotube	Nanometal	None	Gene expression	None
13	Pavagadhi et al., 2014 Water Research [77]	Ag NPs, TiO2 NPs	Ni2+, Mg2+, Zn2+, Cu2+, Cd2+, Fe2+, Cr3+, Hg2+, As5+, Al3+, Pb2+, Mn2+	Metal ions	None	Mortality, Heartbeat, Hatching rate, Uptake	None
14	Wang et al., 2014 Nanotoxicology [84]	TiO2 NPs	Decabromdiphenyl ether	Organic compounds	None	Bioaccumulation, Locomotion activity, Oxidative stress, Gene expression	None
15	Ye et al., 2018 Nanotoxicology [18]	ZnO NPs	GO NPs	Nanocarbon	OECD 236	Mortality, Oxidative stress	None
16	Yan et al., 2014 Nanoscale Research Letters [103]	TiO2 NPs	Bis-Phenol A	Organic compounds	OECD 212	Hatching rate, Immobilization, Heart sac edema, Abnormality rate	None
17	Yan et al., 2018 Environmental Science and Pollution Research [166]	MWCNT	17 β -estradiol	Organic compounds	None	Mortality, Hatching rate, Abnormality rate	None
18	Zhang et al., 2012 Environmental Toxicology and Chemistry [140]	QDs (CdSe)	Cu2+	Metal ions	None	Mortality, Malformations, Hatching rate	None