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. 2021 Jan 9;11(1):153. doi: 10.3390/nano11010153

Figure 2.

Figure 2

Non-covalent physical adsorption functionalization approaches: (A) Positively charged 800 Da polyethyleneimine is immobilized on the negative charged ND surface via electrostatic interactions. Reproduced from [78], with permission from American Chemical Society, 2009; (B) Hormone insulin adsorbed onto the ND surface through electrostatic interactions and H-bonding is used as drug delivery vehicle. Reproduced from [79], with permission from Elsevier, 2009; (C) To increase the aqueous solubility of the steroid receptor-targeted magnetic resonance imaging contrast agent ProGlo (purple circles), it was physically adsorbed to the ND surface. Due to the increased solubility, the resulting ND-ProGlo particles were efficiently accumulated in T47D breast cancer cells expressing progesterone receptors. Reproduced from [80], with permission from American Chemical Society, 2019.