Table 6.
IC50 values (72 h mean ± SD, µM) and selectivity index of 5FU, LY294002, HAA2020, and their combinations in HUVEC cells.
| Drug(s) (ratio) | IC50 | SI | |||
|---|---|---|---|---|---|
| HUVEC | HT29 | HT29-5FU | HCT116 | HCT116-5FU | |
| 5FU | 11.01 ± 1.09 | 55.0 | 0.2 | 57.9 | 0.3 |
| LY294002 | 9.02 ± 0.62 | 1.0 | 0.3 | 0.8 | 0.2 |
| HAA2020 | 32.00 ± 3.54 | 8.5 | 3.5 | 7.8 | 2.4 |
| 5FU: LY294002 (1:1) | 8.56 ± 0.71 | 21.4 | 0.2 | 2.7 | 0.2 |
| 5FU: HAA2020 (1:1) | 27.09 ± 3.00 | 541 | 3.0 | 180.6 | 3.4 |
| LY294002:HAA2020 (1:1) | 15.31 ± 2.11 | 16.1 | 0.8 | 2.5 | 0.5 |
| 5FU: LY294002: HAA2020 (1:1:1) |
3.11 ± 0.19 | 34.5 | 0.2 | 0.8 | 0.1 |
Experiments were repeated ×3 (n = 3).