Table 4.

Significantly over-represented pathways found for the spleen tissue of Boran and N’Dama (p-adjusted $<0.05$).

	Spleen
	Pathway Name	Hit Names	Adjusted p-Value
Boran	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Pou5f1, Stat3	0.0034
N’Dama	Oxidative Stress Induced Senescence	Fos, Jun	0.0033
	BMAL1:CLOCK NPAS2 activates circadian gene expression	Dbp, Ppara	0.0052
	MAPK6/MAPK4 signaling	Foxo1, Jun	0.0052
	Signaling by NOTCH3	Hes1, Pbx1	0.0052
	Cellular responses to stress	Fos, Hsf1, Jun	0.0062
	Fc epsilon receptor (FCERI) signaling	Fos, Jun	0.0067
	Cellular responses to external stimuli	Fos, Hsf1, Jun	0.0135
	MAPK family signaling cascades	Foxo1, Jun	0.0166
	Circadian Clock	Dbp, Ppara	0.0166
	Signaling by NOTCH	Hes1, Pbx1	0.0203
	Generic Transcription Pathway	E2f1, Hes1, Sox9, Stat1, Tead1	0.0243
	Cellular Senescence	Fos, Jun	0.0243
	RNA Polymerase II Transcription	E2f1, Hes1, Sox9, Stat1, Tead1	0.0350
	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPara, Rxra	0.0432