Table 5.

Significantly over-represented pathways found for the lymph node tissue of Boran and N’Dama (p-adjusted $<0.05$).

	Lymph Node
	Pathway Name	Hit Names	Adjusted p-Value
Boran	MAP kinase activation in TLR cascade	Atf1, Atf2, Fos, Jun, Nfkb1	2.37$\times {10}^{-8}$
	Interleukin-17 signaling	Atf1, Atf2, Fos, Jun, Nfkb1	1.83 × 10${}^{-7}$
	MAPK targets/ Nuclear events mediated by MAP kinases	Atf1, Atf2, Fos, Jun	3.66 × 10${}^{-7}$
	MyD88 cascade initiated on plasma membrane	Atf1, Atf2, Fos, Jun, Nfkb1	5.54 × 10${}^{-7}$
	MyD88 dependent cascade initiated on endosome	Atf1, Atf2, Fos, Jun, Nfkb1	7.62 × 10${}^{-7}$
	MyD88:Mal cascade initiated on plasma membrane	Atf1, Atf2, Fos, Jun, Nfkb1	1.03 × 10${}^{-6}$
	MyD88-independent TLR4 cascade	Atf1, Atf2, Fos, Jun, Nfkb1	2.27 × 10${}^{-6}$
	Toll Like Receptor 3 (TLR3) Cascade	Atf1, Atf2, Fos, Jun, Nfkb1	2.88 × 10${}^{-6}$
	Toll-Like Receptors Cascades	Atf1, Atf2, Fos, Jun, Nfkb1	4.39 × 10${}^{-5}$
	MAPK6/MAPK4 signaling	Foxo1, Jun, Myc	4.66 × 10${}^{-4}$
	Innate Immune System	Atf1, Atf2, Fos, Jun, Ltf, Nfkb1	9.27 × 10${}^{-4}$
	Signaling by Interleukins	Atf1, Atf2, Fos, Jun, Nfkb1, Stat1, Stat3	0.0010
	PTEN Regulation	Atf2, Jun	0.0016
	MAPK family signaling cascades	Foxo1, Jun, Myc	0.0028
	Oxidative Stress Induced Senescence	Fos, Jun	0.0069
	Cytokine Signaling in Immune system	Atf1, Atf2, Fos, Jun, Nfkb1, Stat1, Stat3	0.0081
	Fc epsilon receptor (FCERI) signaling	Fos, Jun	0.0138
	PIP3 activates AKT signaling	Atf2, Jun	0.0154
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	Myc, Smad4	0.0171
	NGF signalling via TRKA from the plasma membrane	Atf1, Stat3	0.0171
	Intracellular signaling by second messengers	Atf2, Jun	0.0189
	Immune System	Atf1, Atf2, Fos, Jun, Ltf, Nfkb1, Relb, Stat1, Stat3	0.0241
	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	Mybl2, Myc	0.0311
	Generic Transcription Pathway	E2f1, Mybl2, Myc, Smad4, Sox9, Stat1	0.0338
	Mitotic G2-G2/M phases	Foxm1, Mybl2	0.0381
	Mitotic G1-G1/S phases	E2f1, Mybl2	0.0381
	Interleukin-1 family signaling	Nfkb1, Stat3	0.0430
	Signaling by TGF-beta Receptor Complex	Myc, Smad4	0.0456
	Cellular Senescence	Fos, Jun	0.0482
N’Dama	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Pou5f1, Stat3	0.0042
	BMAL1:CLOCK, NPAS2 activates circadian gene expression	Dbp, Ppara	0.0078
	Circadian Clock	Dbp, Ppara	0.0244
	Factors involved in megakaryocyte development and platelet production	Irf1, Irf2	0.0354
	Interleukin-12 family signaling	Stat1, Stat3	0.0375