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Proposed mechanism of extracellular vesicle-mediated NDPK signaling in endothelial cell activation. Ectopic NDPK-B maintains extracellular ATP and ADP pools by catalyzing phospho-transfer between NTP and NDP substrates. Extracellular ATP and ADP activate the P2Y1 purinergic receptor expressed on vascular endothelium to stimulate known signaling pathways involved in endothelial cell activation, remodeling, and angiogenesis.
