Table 2.
Known substrates and biological roles of ARTD10.
| ARTD10 Substrate | Molecular Outcomes | References |
|---|---|---|
| Aurora Kinase A | Inhibition, suppression of metastasis | [136,137] |
| PCNA | Activation, DNA damage tolerance, replicative stress | [136,138] |
| Myc and Ran as nuclear substrates | Inhibition | [87] |
| GSK3β | Inhibition | [87,150] |
| Histone 3 | Proliferation | [154] |
| Tubulin-β, Exportin-5, SRPK2, PKM, EF1-α1, UBEC3 | N.D. | [133] |
| PLK1 | MARylation inhibits activity and oncogenic function | [135] |
| NEMO (IKK gamma) | Inhibition of NF-kB, inhibition polyubiquitination, anti-inflammatory role | [132] |
| ARTD10 | Alleviation of replicative stress and increase of EMT | [136] |
| ARTD10 | Increases Warburg enzymes, glycolysis. Reduces oxidative stress, increases AMPK activity, reduces ATP levels, decreases cancer proliferation | [152,153] |