Table 3.
Summary of some modified proteins identified by proteomics in fish infectious diseases.
| Aetiological Agent | Species | Tissue | Modified Protein Groups | Reference |
|---|---|---|---|---|
| Vírus | ||||
| Infectious spleen and kidney necrosis virus (ISKNV) (Megalocytivirus) | Zebrafish (Danio rerio) | Spleen | Cytoskeletal proteins, stress response, lipoprotein and carbohydrate metabolism, signal transduction, proteolysis, metabolic and catabolic processes | [89] |
| Megalocytivirus | Turbot (Scophtalmus maximus) | Spleen | Cytoskeleton proteins, molecular biosynthesis, cellular signal transduction and chaperone proteins | [187] |
| Salmonid alphavirus subtype 3 (SAV3) | Atlantic salmon (Salmo salar) | Serum | Humoral components of immunity | [94] |
| Rhabdovirus | Zebrafish (Danio rerio) | Fins | Proteins of the glycolytic pathway and cytoskeleton components | [188] |
| Spring viremia of carp virus | Zebrafish (Danio rerio) | Plasma | Vitellogenin and Gig2 | [189] |
| Viral septicemia hemorrhagic virus | Rainbow trout (Oncorhynchus mykiss) | Red blood cells from blood and head kidney | Proteins related to viral transcription | [190] |
| Cyprinid herpesvirus-2 | Crucian carp (Carassius carassius) | Head kidney | Cytoskeleton, transport, immunologic, intracellular and physiologic proteins | [191] |
| Bacteria | ||||
| Aeromonas salmonicida | Rainbow trout (Oncorhynchus mykiss) | Liver | Complement system and acute phase response proteins | [192] |
| Aeromonas salmonicida | Rainbow trout (Oncorhynchus mykiss) | Spleen | Immune system, signaling molecules and interaction | [193] |
| Aeromonas hydrophila | Common carp (Cyprinus carpio) | Intestinal mucosa | Proteins involved in stress and immune response | [194] |
| Aeromonas hydrophila | Zebrafish (Danio rerio) | Gills | Stress and immune response | [91] |
| Edwardsiella ictaluri | Channel catfish (Ictalurus punctatus) | Head kidney | Macrophage function, cellular stress response, cellular energy production and metabolism | [195] |
| Yersinia ruckeri | Rainbow trout (Oncorhynchus mykiss) | Head kidney and spleen | Immune system, cellular, metabolic, developmental, multicellular, adhesion, regulation and response to stimulus | [95] |
| Yersinia ruckeri | Rainbow trout (Oncorhynchus mykiss) | Intestine | Metabolic process biological regulation, cellular processes and component organization | [196] |
| Vibrio anguillarum | Atlantic cod (Gadus morhua) | Mucus | Proteins involved in the immune system | [83] |
| Streptococcus parauberis | Olive flounder (Paralichthys olivaceus) | Kidney | Proteins involved in immune response, cellular recovery and glycoprotein synthesis | [197] |
| Moraxella sp. | Gilthead seabream (Sparus aurata) | Kidney | Mitochondrial proteins, cellular response to oxidative stress, infection and inflammation | [198] |
| Parasites | ||||
| Ichthyophthirius multifiliis | Common carp (Cyprinus carpio) | Mucus | Proteins involved in the immune and inflammatory response | [199] |
| Lepeophtheirus salmonis | Atlantic salmon (Salmo salar) | Mucus | Proteins involved in glycolysis, peptide synthesis, immune and defence response | [82] |
| Amyloodinium ocellatum | Gilthead seabream (Sparus aurata) | Plasma | Proteins involved in the acute-phase response, inflammation, lipid transport, homeostasis and wound healing | [88] |
| Neoparamoeba perurans | Atlantic salmon (Salmo salar) | Gill and skin mucus | Proteins involved in cell to cell signalling and inflammation pathway | [189] |
| Neoparamoeba perurans | Atlantic salmon (Salmo salar) | Gill and skin mucus | Proteins involved in cell cycle regulation, cytoskeletal regulation, oxidative metabolism and immunity | [201] |