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cTnI organization. Exons, RCM mutations and binding sites are indicated. A-TM: a second actin-tropomyosin binding site, PP (PKA): Serines 22, 23 phosphorylated by the proteinkinase A (PKA). The RCM mutations mainly affect exon 7 and 8, encoding for the inhibitory region, TnC binding domains and the A-TM site. The figure was created using PowerPoint (Microsoft).
