Figure 5.

Correlations among the effects of 1 mM lidocaine on TRPM7 function, cell viability, and cell migration. (A). Suppression of migration vs. viability in 7 breast cancer cell lines and HEK-M7 cells (slope = 0.7954, r² = 0.4016). (B). Suppression of viability vs. inhibition of TRPM7 function for HEK-M7 cells and the four breast cancer cells showing significant changes in fluorescence in the flux quenching assay (slope = 0.7426, r² = 0.9351). (C). Suppression of migration vs. inhibition of TRPM7 function for HEK-M7 cells and the four breast cancer cells showing significant changes in fluorescence in the flux quenching assay (slope = 0.7563, r² = 0.7047). TRPM7 function inhibition was calculated from the average of the quench fluorescence during the last 30 s. Linear regression was plotted and the 95% confidence band of the best fit line was shown.