Figure 2.

Confocal microscopy images of living Candida albicans cells treated for 15 min with the fluorescein isothiocyanate-labeled Ab gene-peptide L12P (A). The peptide was on the yeast cell surface and entered into yeast cells within a few minutes; empty vacuoles were seen. Some yeast cells were no longer viable, as assessed by propidium iodide internalization (B). (C) merge of panels A and B. Bar: 2 µm. The rapidity of the killing effect suggests a membrane-disrupting mode of action.