Table 3.
Deposited doses for in vivo study compared with in vitro.
| Group | Treatment Conc. (µg/mL) | Aerosol Conc. (µg/m3) | Deposited Dose Lung (µg) | Deposited Dose Alveolar (µg) | Deposited Dose Tracheobronchial (µg) | Dose Per Unit Area † (ng/cm2) |
|---|---|---|---|---|---|---|
| In vitro | ||||||
| FeOx-mix A | 0.003 | - | - | - | - | 0.99 |
| FeOx-mix B | 0.03 | - | - | - | - | 9.9 |
| FeOx-mix C | 0.3 | - | - | - | - | 99 |
| Fe3O4 | 0.03 | - | - | - | - | 9.9 |
| In vivo | ||||||
| FeOx-mix High Dose | - | 508 | 8.4 | 5.8 | 2.6 | 110 |
| Fe3O4 High Dose | - | 487 | 8.0 | 5.6 | 2.5 | 110 |
| Fe3O4 Low Dose | - | 48 | 0.8 | 0.6 | 0.24 | 11 |
† Mass dose per unit cell culture surface area for in vitro study and per unit tracheobronchial surface area for in vivo.