Table 3.
Association between ADRD and pain intensity for pain medication and central nervous system acting medications use during 90-days prior to hospitalization in FY 2013 among 96,224 Veterans 65 and older with moderate to severe pain.
| Pain Medication Use, aOR (95% CI) | ||||
| Predictor | Opioids | Gabapentinoids | Acetaminophen | NSAIDs |
| (1) ADRD diagnosis vs. non-ADRD |
0.90 (0.87, 0.94) |
1.30 (1.25, 1.36) |
1.08 (1.04, 1.12) |
0.93 (0.89,0.97) |
| (2) Severe pain vs. Moderate pain |
1.93 (1.87,1.99) |
1.58 (1.52, 1.64) |
1.62 (1.57,1.67) |
1.36 (1.31, 1.41) |
| Central Nervous System Acting Medications, aOR (95% CI) | ||||
| Antipsychotics | Antidepressants | Sedative/Hypnotics | ||
| (1) ADRD diagnosis vs. non-ADRD |
3.44 (3.25, 3.65) |
2.36 (2.28, 2.45) |
1.38 (1.32, 1.44) |
|
| (2) Severe pain vs. Moderate pain |
1.20 (1.13, 1.28) |
1.34 (1.30, 1.38) |
1.35 (1.30, 1.40) |
|
Abbreviations: aOR, Adjusted Odds Ratio; CI, Confidence Intervals; ADRD Alzheimer’s Disease and related dementias. aOR was estimated using a logistic regression of each drug prescription during the 90-days prior to hospitalization as a binary outcome adjusted for 5-yr age groups, sex, marital status, race/ethnicity groups, and Charlson Comorbidity Index.