Table 4.
Interactions associations between ADRD by pain intensity for pain medication and central nervous system acting potentially inappropriate medications use during 90-days prior to hospitalization in FY 2013 among 96,224 veterans 65 and older with moderate to severe pain.
| Pain Medication Use, aOR (95% CI) | |||||
| Opioids | Gabapentinoids | Acetaminophen | NSAIDs | ||
| p value for ADRD by Pain level interaction | 0.134 | 0.044 | 0.457 | 0.830 | |
| ADRD | Severe vs. Moderate pain | 2.04 (1.89,2.20) |
1.71 (1.57, 1.86) |
1.66 (1.54,1.80) |
1.37 (1.24, 1.51) |
| Non-ADRD | Severe vs. Moderate pain | 1.91 (1.85, 1.98) |
1.55 (1.49, 1.61) |
1.61 (1.55, 1.67) |
1.36 (1.30, 1.41) |
| Central nervous System Acting Medications, aOR (95% CI) | |||||
| Antipsychotics | Antidepressants | Sedative/Hypnotics | |||
| p value for ADRD by Pain level interaction | <0.001 | <0.001 | 0.503 | ||
| ADRD | Severe vs. Moderate pain | 0.97 (0.87, 1.08) |
1.18 (1.10, 1.26) |
1.38 (1.27,1.51) |
|
| Non-ADRD | Severe vs. Moderate pain | 1.34 (1.24,1.44) |
1.39 (1.34, 1.43) |
1.34 (1.29,1.40) |
|
Abbreviations: aOR, Adjusted Odds Ratio; CI, Confidence Intervals; ADRD Alzheimer’s Disease and related dementias. aOR was estimated using a logistic regression of each drug prescription during the 90-days prior to hospitalization as a binary outcome adjusted for 5-yr age groups, sex, marital status, race/ethnicity groups, and Charlson Comorbidity Index.