Figure 1.

Leptin receptor-driven signalling in neurons. The key signalling pathways activated following leptin binding to leptin receptors (LepRs) and subsequent activation of janus tyrosine kinase (JAK)2 are shown including signal transducers and activators of transcription (STAT3), Ras-Raf-MEK-MAPK and phosphoinositide 3-kinase (PI3K), which ultimately lead to gene transcriptional changes or altered ion channel function. LepR signalling is terminated following the production of suppressor of cytokine signalling (SOCS)3.