4E-BP1 |
Eukaryotic Translation Initiation Factor 4E |
AKT |
Protein Kinase B |
ALL |
Acute lymphoblastic leukemia |
AML |
Acute myeloid leukemia |
ATP |
Adenosine triphosphate |
Avg |
Average |
B-ALL |
B-acute lymphoblastic leukemia |
BCL-2 |
BCL2 Apoptosis Regulator |
BCL-6 |
BCL6 Transcription Repressor |
BCR |
B-cell receptor |
BCR- |
B-cell receptor negative |
BCR+ |
B-cell receptor positive |
BIM |
Bcl-2-like protein 11 |
BLNK |
B Cell Linker |
BTK |
Bruton Tyrosine Kinase |
CD22 |
B-Lymphocyte Cell Adhesion Molecule |
CD79B |
B-Cell Antigen Receptor Complex-Associated Protein Beta Chain |
CDC25C |
Cell Division Cycle 25C |
CDK1 |
Cyclin Dependent Kinase 1 |
CLL |
Chronic lymphocytic leukemia |
DAPP1 |
Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1 |
DLBCL |
Diffuse large B-cell lymphoma |
DN |
Dominant negative |
Ento |
Entospletinib |
ERK |
Extracellular signal-regulated kinases |
FDA |
Food and Drug Administration |
FL |
Follicular lymphoma |
FOXO1 |
Forkhead Box O1 |
GoF |
Gain-of-function |
GS-9973 |
Entospletinib, SYK inhibitor |
GSK3β |
Glycogen Synthase Kinase 3 Beta |
IC50 |
Half maximal inhibitory concentration |
Igµ |
Immunoglobulin heavy chains |
IgG |
Immunoglobulin G |
IgM |
Immunoglobulin M |
Ig-α |
Immunoglobulin (Ig)α cytoplasmic domain |
Ig-β |
Immunoglobulin (Ig)β cytoplasmic ddomain |
IL7R |
Interleukin 7 Receptor |
ITAMs |
Immunoreceptor tyrosine-based activation motifs |
LAT2 |
Linker For Activation Of T Cells Family Member 2 |
LoF |
Loss-of-function |
MAP |
Mitogen-activated protein |
MCL |
Mantle cell lymphoma |
MEK |
Mitogen-activated protein kinase kinase |
MFI |
Mean fluorescence intensity |
MLL
|
Mixed lineage leukemia |
p |
Phospho |
p53 |
Tumor Protein P53 |
p63 |
Tumor protein P63 |
p73 |
Tumor protein P73 |
PCA |
Principle component analysis |
PI3K |
Phosphoinositide 3-kinase |
PRT318 |
SYK Inhibitor |
PTPN6 |
Protein Tyrosine Phosphatase Non-Receptor Type 6 |
R406 |
SYK Inhibitor |
Raf |
RAF proto-oncogene serine/threonine-protein kinase |
RAS |
Rat sarcoma |
RPS6KB1 |
Ribosomal Protein S6 Kinase B1 |
S |
Serine |
Ser |
Serine |
SHP-1 |
Protein Tyrosine Phosphatase Non-Receptor Type 6 |
SPRY2 |
Sprouty RTK Signaling Antagonist 2 |
SYK |
Spleen tyrosine kinase |
TAC |
Transcriptome Analysis Console |
TCF3-PBX1 |
Fusion gene Transcription Factor 3 and PBX Homeobox 1 |
TNF |
Tumor necrosis factor |
TP53 |
Tumor Protein P53 |
Tyr |
Tyrosin |
VEGFA |
Vascular Endothelial Growth Factor A |
wt |
Wild type |
Y |
Tyrosin |