Table 5.
The area under the curve, cut-off value, sensitivity, specificity, p value, likelihood ratio+, likelihood ratio− and post-test probability resulting from ROC analysis of level of HE4 measured before surgery, during the third chemotherapy to predict ovarian cancer relapse.
| Pre Test Probability | Area Under the Curve | Younden Index | Sensitivity | Specificity | p Value | Likehood Ratio+ | Likehood Ratio− | Post Test Odd | Post Test Probability | |
|---|---|---|---|---|---|---|---|---|---|---|
| During 3rd Cycle BRCA |
0.4 | 0.92 | > 66 | 75 | 99.9 | p < 0.001 | 750 | 0.25 | 500 | 0.99 |
| During 3rd Cycle WT |
0.4 | 0.87 | > 66 | 78 | 91 | p < 0.001 | 8.9 | 0.24 | 5.9 | 0.86 |
| Pre-Surg. BRCA |
0.4 | 0.79 | > 1767 | 99,9 | 73 | p = 0.019 | 3.7 | 0.001 | 2.4 | 0.71 |
| Pre-Surg. WT |
0.4 | 0.61 | > 231 | 63 | 61 | p = 0.17 | 1.6 | 0.62 | 1.06 | 0.52 |