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. 2021 Jan 10;10(1):86. doi: 10.3390/antiox10010086

Figure 1.

Figure 1

Protective effect of Rut in acetaminophen (APAP)-induced hepatotoxicity in mice. Mice were orally administered 5 or 20 mg/kg of Rut once daily for 7 consecutive days. Control and APAP-treated groups received only the appropriate vehicle orally. After fasting for 12 h, mice were intraperitoneally injected with 300 mg/kg APAP and euthanized after 8 h. Hepatotoxicity was analyzed by measuring serum alanine aminotransferase (ALT) (A) and aspartate aminotransferase (AST) (B) activities and hepatic malondialdehyde (MDA) (C) and glutathione (GSH) (D) contents. Representative hematoxylin and eosin-stained liver samples for histopathological analysis at 100× magnification (E). # Significantly different from the control (p < 0.05). * Significantly different from the APAP-treated group (p < 0.05).