Table 2.
Inhibitory effects of compounds 1–7 from Penicillium citrinum on superoxide anion generation by human neutrophils, in response to fMLP.
| Compounds | IC50 (μM) a |
|---|---|
| Epiremisporine C (1) | >50 |
| Epiremisporine D (2) | 6.39 ± 0.40 e |
| Epiremisporine E (3) | 8.28 ± 0.29 d |
| Epiremisporine B (4) | 3.62 ± 0.61 e |
| Penicitrinone A (5) | 2.67 ± 0.10 e |
| 8-Hydroxy-1-methoxycarbonyl-6-methylxanthone (6) | >50 |
| Isoconiochaetone C (7) | 38.35 ± 0.21 c |
| Ibuprofen b | 27.85 ± 3.56 c |
a Concentration necessary for 50% inhibition (IC50). b Ibuprofen (a fMLP receptor antagonist) was used as a positive control. Results are presented as average ± SEM (n = 3). Values are expressed as average ± SEM (n = 3). c p < 0.05; d p < 0.01; e p < 0.001 compared with the control.