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. 2021 Jan 11;11(1):107. doi: 10.3390/diagnostics11010107

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The miRNA–mRNA interaction network analysis and enriched KEGG pathways for target genes. (a) A significant miRNA target gene network is constructed by submitting the 28 selected miRNAs to the miRNet database. (b) The network represents KEGG pathways for target genes of the most significant miRNAs. Representations are generated by ClueGO for functionally grouped networks of enriched KEGG pathways. The parameters of GlueGo were set as follows: GO term fusion selected; only display pathways with p < 0.001 with Bonferroni step-down analysis; and kappa score of 0.4. MAPK: Mitogen-activated protein kinase; HIF-1: Hypoxia-inducible factor; PD-L1: Programmed cell death-ligand 1; PD-1: Programmed cell death-1; PI3K: Phosphatidylinositol 3-kinase; TNF: Tumor necrosis factor; FoxO: Forkhead box protein O; EBV: Epstein-barr virus.