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. 2021 Jan 12;13(2):259. doi: 10.3390/cancers13020259

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Isoform-specific expression and survival prognosis of SPCA genes in triple receptor negative breast cancer (TNBC). (A,B) Expression of (A) SPCA2 and (B) SPCA1 was analyzed in receptor positive and negative (TNBC) breast cancers from TCGA database; n = 290 for receptor-negative patients and n = 1222 for receptor-positive patients. (C,D) Kaplan–Meier analysis of regression-free survival in patients stratified by (C) SPCA2 or (D) SPCA1 expression level. Data from KMplotter selected ER, PR, and HER2 (negative). Hazard ratio = 0.62 (0.4–0.95); Logrank test, n = 125 in low SPCA2 group, and n = 130 in high SPCA2 group. Hazard ratio= 1.38 (0.91–2.11), Logrank test, n = 139 in low SPCA1 group and n = 116 in high SPCA1 group. **** p < 0.0001.