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. 2021 Jan 11;13(1):201. doi: 10.3390/nu13010201

Figure 2.

Figure 2

Genistein (GEN) after tamoxifen response prevents local recurrence in the HFD offspring. (A) Experimental design to study the effects of starting genistein feeding after complete response to tamoxifen on local mammary tumor recurrence in the offspring of control or high fat diet (HFD) fed dams. (B) Maternal exposure to HFD did not change initial response to tamoxifen (HFD, n = 108 tumors), compared to control offspring (n = 113 tumors). (C) After tamoxifen therapy, there was no difference in tumor recurrence among control offspring treated with GEN (con/GEN; out of 19 tumors) or not treated with GEN (control/CD; out of 21 tumors). Maternal HFD significantly increased (p = 0.026) mammary tumor recurrence after tamoxifen therapy (HFD/CD; out of 15 tumors), compared with control offspring. GEN supplementation significantly decreased (p = 0.018) tumor recurrence in the HFD offspring (HFD/GEN; out of 18 tumors). The data are shown as percentage of tumors. Statistical significance according to Chi-Square test.