Figure 7.

Microbial signatures associated with local recurrence of the estrogen receptor positive breast tumor after tamoxifen treatment in a rat model. (A) The abundance of the family Lachnospiraceae was significantly higher in rats with tumor recurrence. (B) A microbial signature consisting of Lachnospiraceae (numerator) and Christensenellaceae (denominator) accurately predicted the recurrence status. AUC = Area under the ROC (receiver operating characteristics) curve. R: with local recurrence; NR: without local recurrence. (C): The top 20 microbial predictors that contributed to the classification accuracy between the groups with (R) or without (NR) local recurrence. (Un.g) = unclassified genus. ** p < 0.01.