Table 2.
Population pharmacokinetic parameters of paclitaxel of the covariate model of BSA, SMI, VAT, and SMD.
| Parameter (Unit) | Covariate Model BSA |
Covariate Model SMI |
Covariate Model VAT |
Covariate Model SMD |
||||
|---|---|---|---|---|---|---|---|---|
| dOFV | REF | dOFV | +29 | dOFV | +34 | dOFV | +25 | |
| Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | |
| VMEL (µmol/h) | 31.6 | 26.7–37.4 | 32.4 | 26.7–40.6 (11) | 31.9 | 26.0–39.0 | 31.6 | 34.7–38.9 |
| V1 (L) | 24.0 | 20.8–27.6 | 24.7 | 21.3–28.4 | 25.0 | 21.8–28.4 | 25.2 | 22.0–28.8 |
| V3 (L) | 267 | NA | 267 | NA | 267 | NA | ||
| KMEL (µmol/L) | 0.40 | 0.29–0.52 | 0.51 | 0.37–0.73 | 0.49 | 0.33–0.68 | 0.55 | 0.36–0.74 |
| VMTR (µmol/h) | 179 | 138–225 | 153 | 119–199 | 148 | 111–188 | 144 | 113–193 |
| KMTR (µmol/L) | 1.91 | 1.37–2.67 | 1.80 | 1.46–1.98 | 1.75 | 1.24–2.39 | 1.73 | 1.15–2.36 |
| K21 (h−1) | 2.34 | 1.85–2.96 | 2.16 | 1.69–2.72 | 2.09 | 1.64–2.65 | 2.15 | 1.70–2.69 |
| Q (L/h) | 20.7 | 18.0–23.3 | 19.8 | 17.0–23.0 | 19.6 | 17.0–22.3 | 19.9 | 16.6–23.0 |
| Body composition on VMEL | 1.25 | 1.03–1.51 | 0.34 | 0.24–0.44 | 0.09 | 0.06–0.12 | 0.03 | 0.02–0.04 |
| Age on VMEL | −0.30 | −0.39–0.22 | −0.30 | −0.32–0.30 | −0.50 | −0.65–0.34 | −0.28 | −0.36–0.20 |
| Gender on VMEL | 1.07 | 0.96–1.19 | 1.20 | 1.06–1.34 | 1.23 | 1.09–1.37 | 1.30 | 1.15–1.47 |
| Bilirubin on VMEL | −0.17 | NA | −0.17 | NA | −0.17 | NA | −0.17 | NA |
| Interindividual variability | ||||||||
| VMEL (%) | 24.3 | 20.8–28.3 | 28.6 | 24.9–33.3 | 27.4 | 24.0–32.4 | 29.8 | 25.5–34.9 |
| V1 (%) | 39.1 | 33.2–45.3 | 38.1 | 31.3–43.7 | 37.7 | 31.9–45.4 | 37.5 | 30.6–43.5 |
| Q (%) | 62.0 | 52.3–72.9 | 62.8 | 52.8–74.0 | 64.3 | 52.8–75.6 | 62.4 | 50.7–74.3 |
| Residual variability | ||||||||
| σprop (%) | 22.5 | 20.1–25.5 | 22.4 | 20.2–25.5 | 22.6 | 20.0–25.5 | 22.4 | 19.8–25.3 |
The data represent the following: BSA = body surface area, dOFV = difference Objective Function Value, K21 = rate constant of the distribution from the first peripheral compartment to the central compartment, NA = not applicable, Q = intercompartmental clearance between the central and second peripheral compartment, σprop = proportional residual error, SMD = skeletal muscle density, SMI = skeletal muscle index, VAT = visceral adipose tissue, V1 = volume of central compartment, V3 = volume of the second peripheral compartment, VMEL = maximal elimination rate, VMTR = maximal transport rate from the central to the first peripheral compartment, KMEL = plasma concentration at half VMEL, and KMTR = plasma concentration at half VMTR.