Table 5.
Acute and late complications related to image-guided proton therapy.
| Adverse Event | BCLC 0–A 52 Patients (Grade 2/3) |
BCLC B–D 19 Patients (Grade 2/3) |
Total Number (Grade 2/3) |
|---|---|---|---|
| Acute toxicity | |||
| Hepatobiliary enzyme | 0/0 | 1/0 | 1/0 |
| Cytopenia | 0/0 | 0/0 | 0/0 |
| Dermatitis | 2/0 | 2/0 | 4/0 |
| Decrease in Child–Pugh score ≥ 2 | 0 | 0 | 0 |
| Radiation pneumonitis1 | 0/0 | 0/0 | 0/0 |
| Late toxicity | |||
| Hepatobiliary enzyme | 0/0 | 0/0 | 0/0 |
| Cytopenia | 0/0 | 0/0 | 0/0 |
| Dermatitis | 0/0 | 0/1 | 0/1 |
| Decrease in Child–Pugh score ≥ 2 | 1 2 | 3 2 | 4 2 |
| Radiation pneumonitis 1 | 0/0 | 0/0 | 0/0 |
| Soft-tissue inflammation | 1/0 | 0/0 | 1/0 |
| Rib fracture | 1/0 | 0/0 | 1/0 |
1 Pneumonitis occurring within the irradiation field within and after 3 months was defined as acute and late radiation pneumonitis, respectively; 2 potentially due to original cirrhosis and infection.