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. 2021 Jan 7;10(1):94. doi: 10.3390/cells10010094

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of the 12 most frequently mutated genes associated simultaneously with Notch signaling and EMT, in 1039 breast cancers (TCGA sequencing project). In contrast to Figure 3, tumors have been sorted according to most frequent mutations (CCND1, MYC) to illustrate the high frequency of amplifications. (a) Sorted incidence of mutations, including amplifications, deletions, point mutations, and RNA overexpression, as generated by the cBioPortal browser. Data have been sorted according to type of mutation/genetic alteration. (b) Tumors with high frequency of genetic alterations in Notch/EMT target or signature genes also show a higher degree of genetic instability. (c) Tumors with high levels of Notch/EMT-related genetic alterations more frequently belong to the triple-negative and basal-like breast cancers that lack expression of progesterone receptor (PR). (d) Corresponding finding for expression of estrogen receptor (ER) in the same tumors, as analyzed by immunohistochemistry (IHC).