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. 2021 Jan 10;11(1):45. doi: 10.3390/metabo11010045

Figure 6.

Figure 6

Energetic and tricarboxylic acid (TCA) cycle metabolite disturbances in CKD. Graphical depiction of the TCA cycle with quantified metabolites presented as Box and Whisker plots (showing 95% confidence intervals) in control (green dots) and CKD mice (red dots). The y-axis values represent metabolite concentrations in units of millimolars. A two-tailed unpaired t-test was performed to determine the statistical significance, with * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. Abbreviations: Kid = kidney, Hrt = heart, Liv = liver, and SkM = skeletal muscle.