Table 3.

Summary of magnesium supplementation studies for blood pressure in Controlled Hypertensives (subjects treated with antihypertensive medications, normotensive at baseline).

Study Citation	Mg Dose, mg/day	Form of Mg	BP Status at Baseline, NT or HT	Medical Status at Baseline, T or UT	BP Outcome 1	Notes
Henderson et al. (1986) [70]	304	MgO	NT	T	No change	Potassium depleting diuretics ≥ 6 months
Itoh et al. (1997) [71]	413–583	Mg(OH)2	NT	T and UT	No change 2,3	Some subjects were borderline HT; medications kept constant “when necessary” (medications not specified)

¹ Studies showing a statistically significant decrease in both SBP and DBP from baseline as well as placebo (if reported) were labeled “Decrease”; all others were deemed “No change” in BP. ² Rise in Na excretion; decrease in serum Na. ³ Faulty baseline statistics; final SBP and DBP significantly lower than baseline but change in SBP and DBP not significantly different from those of placebo, thus the “No change” categorization. Only as a percentage of run-in, pre-baseline value was final Mg SBP significantly lower than placebo’s percentage of run-in SBP. Abbreviations: BP, blood pressure, NT, normotensive at baseline; HT, hypertensive at baseline; UT, most or all subjects treatment naïve or not taking any antihypertensive medications during or before the study; T, most or all subjects treated with antihypertensive medications including diuretics.