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. 2021 Jan 11;22(2):664. doi: 10.3390/ijms22020664

Figure 5.

Figure 5

Nuclear translocation of Smad2/3 in response to the allograft supernatants. Gingival fibroblasts were exposed to aqueous supernatants of OraGRAFT® Demineralized Cortical Particulate (SC) and OraGRAFT® Prime (SF) with and without the TGF-β receptor type I kinase-inhibitor SB431542. Recombinant TGF-β1 served as a positive control. Without (wo) is the serum-free medium alone. The positive signals induced by SC and SF are indicated by the nuclear staining that is blocked by the SB431542.