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. 2021 Jan 8;9(1):52. doi: 10.3390/biomedicines9010052

Figure 8.

Figure 8

SIRT1 activation inhibits the levels of inflammatory mediators in heart tissues. (a) VCAM-1, p-p65, and total p65 protein expression in the heart tissues were detected by Western blotting. VCAM-1 and p-p65 protein levels were quantified by densitometric analysis. (b) TNFα, IL-1β, IL-6, and VCAM-1 mRNA levels in the heart tissues were quantified using qPCR. All data are presented as means ± SEM of three independent experiments (n = 5 mice in each group; * p < 0.05 vs. WT mice. # p < 0.05 vs. CRIF1 EKO mice).