Table 2.
Histopathological scoring of disease in tumors arising on murine skin after treatment with chemical carcinogens. After completing 20 weeks of TPA treatment following one-time treatment with DMBA, mice were held for an additional 5 weeks to monitor malignant progression. The number of mice and total tumors/foci evaluated is indicated in parentheses. The number of foci scored as having each disease grade is indicated for each group of mice.
| Disease Grade | Experimental Groups | ||
|---|---|---|---|
|
R26-LSL-MCPyV168 (n = 8 mice, n = 24 foci) |
K14E6/E7 (n = 6 mice, n = 20 foci) |
K14Cre-MCPyV168 (n = 7 mice, n = 26 foci) |
|
| Dysplasia Grade 1 | 12 | 6 | 14 |
| Dysplasia Grade 2 | 4 | 6 | 4 |
| Dysplasia Grade 3 | 0 | 2 | 2 |
| SCC Grade 1 | 8 | 4 | 6 |
| SCC Grade 2 | 0 | 1 | 0 |
| SCC Grade 3 | 0 | 1 | 0 |