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. 2021 Jan 9;22(2):608. doi: 10.3390/ijms22020608

Figure 7.

Figure 7

Hypothetic model of ART induction of monocyte phenotypic changes. In an immunosuppressive environment, JAK2/STAT3 are activated after IL-4 release, which increases CD206 and CD163 expression, and decreases MCP-1/IL-1β release and NO production. In contrast, ART inhibits activation of JAK2/STAT3 pathway, increasing HLA-DR expression, NO production, and MCP-1/IL-1β release, and leads to an accumulation of monocytes with an inflammatory profile. In return, CD206, CD163, and CD16 expressions decrease. In co-culture with leukemic cells, monocytes-ART-programmed assumed a tumoricidal profile and induces apoptosis of leukemic cell. These data suggest that ART switches monocytes to an inflammatory and antitumoral profile that could be useful for control tumor progression and re-educates monocytes inside of a tumor microenvironment.