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. 2021 Jan 9;11(1):44. doi: 10.3390/metabo11010044

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Metabolic pathway analysis and cluster heatmap analysis between mild-to-moderate (MM) and severe groups. (A) Summary of pathway analysis and meta-analysis result. (B) Enrichment analysis on a pattern of interest identified in dataset A1 (negative ion mode). P0: Caffeine metabolism; P1: Glyoxylate and dicarboxylate metabolism; P2: Citrate cycle (TCA cycle); P3: Purine metabolism; P4: Lysine degradation. The vertical dashed line in the bar plot is the threshold of p = 0.05. (C) Enrichment analysis on a pattern of interest in A1 (positive ion mode). P0: Glycine, serine and threonine metabolism; P1: Glyoxylate and dicarboxylate metabolism; P2: Cysteine and methionine metabolism; P3: Citrate cycle (TCA cycle); P4: Selenocompound metabolism.