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. 2021 Jan 10;10(2):227. doi: 10.3390/jcm10020227

Figure 3.

Figure 3

Immunohistochemical profile of human cutaneous Meissner corpuscles. Immunohistochemical localization of S100 protein (S100), neuron-specific enolase (NSE), CD34, Glut-1, vimentin (VIM), neurofilament protein (NFP), lumican (LUM) and PIEZO2 in human digital Meissner corpuscles. (a,b) Serial sections of the same corpuscle showing the lamellar cells (S100-protein-positive) and the axon (NSE-positive); (c) immunolabeling of the endoneurial capsule (CD34-positive); (d–f) images of double immunofluorescence demonstrating that S100P and VIM colocalize in lamellar cells. (g,h) variable relationships of the axon (NFP-positive) with the lamellar cells (S100P- or VIM-positive); (i,j) endoneurial, but not perineurial, nature of the capsule in Meissner corpuscles (CD34-positive; arrows); (k) expression of lumican, a component of the extracellular matrix, in association with the lamellar cells; (l) expression of PIEZO2, a mechanoprotein involved in mechanotransduction in the axon of Meissner corpuscles. ed: epidermis; MC: Meissner corpuscles. bv: blood vessels (in (c)).