Table 5.
List of the most abundant transporter classes, including their representative subclasses and families. Numbers in parenthesis indicate the total number of differentially expressed transcripts assigned to that specific class, subclass, and family. Direction of the arrow represents whether the representative transcript is downregulated (↓) or upregulated (↑).
| Class | Class Description | Subclass | Subclass Description | Family | Family Description | Representative Transcript | Effect |
|---|---|---|---|---|---|---|---|
| TC 8 (45) | Accessory Factors Involved in Transport | TC 8.A (43) | Auxiliary transport proteins | TC 8.A.24 (6) | The Ezrin/Radixin/Moesin-binding Phosphoprotein 50 (EBP50) family | Syntenin-1 | ↓ |
| TC 8.A.23 (4) | The Basigin family | Tyrosine-protein kinase Abl | ↓ | ||||
| TC 8.A.104 (4) | The 5’-AMP-activated protein kinase (AMPK) family | Serine/threonine-protein kinase pim-3 | ↓ | ||||
| TC 8.B (2) | Ribosomally synthesized protein/peptide toxins/agonists that target channels and carriers | TC 8.B.14 (2) | The Sea Anemone Peptide Toxin, Class 1 (BgK) family | Matrix metalloproteinase-24 | ↓ | ||
| TC 3 (37) | Primary Active Transporters | TC 3.A (33) | P-P-bond hydrolysis-driven transporters | TC 3.A.2 (6) | The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily | V-type proton ATPase subunit a1 | ↓ |
| TC 3.A.16 (6) | The Endoplasmic Reticular Retrotranslocon (ER-RT) family | 26S proteasome regulatory subunit 6A | ↑ | ||||
| TC 3.A.5 (4) | The General Secretory Pathway (Sec) family | Putative U5 small nuclear ribonucleoprotein 200-kDa helicase | ↓ | ||||
| TC 3.D (4) | Oxidoreduction-driven transporters | TC 3.D.1 (3) | The H+ or Na+-translocating NADH Dehydrogenase (NDH) family | NADH dehydrogenase (ubiquinone) iron-sulfur protein 8, mitochondrial | ↑ | ||
| TC 3.D.4 (1) | The Proton-translocating Cytochrome Oxidase (COX) Superfamily | Cytochrome c oxidase subunit 7A1, mitochondrial | ↑ | ||||
| TC 1 (34) | Channels/Pores | TC 1.A (17) | α-Type Channels | TC 1.A.115 (6) | The Nonselective Cation Channel-2 (NSCC2) family | Dehydrogenase/reductase SDR family member 12 | ↑ |
| TC 1.A.17 (2) | The Calcium-dependent Chloride Channel (Ca-ClC) family | Transmembrane channel-like protein 7 | ↓ | ||||
| TC 1.I (10) | Membrane-bounded Channels | TC 1.I.1 (10) | The Nuclear Pore Complex (NPC) family | MAP kinase-activated protein kinase 2 | ↓ | ||
| TC 9 (27) | Incompletely Characterized Transport Systems | TC 9.A (12) | Recognized Transporters of Unknown Biochemical Mechanism | TC 9.A.3 (4) | The Sorting Nexin27 (SNX27)-Retromer Assembly Apparatus | Ras-related protein Rap-1b | ↓ |
| TC 9.A.63 (3) | The Retromer-dependent Vacuolar Protein Sorting (R-VPS) family | Cell division control protein 42 homolog | ↓ | ||||
| TC 9.B (15) | Putative uncharacterized transport proteins. | TC 9.B.87 (5) | The Selenoprotein P Receptor (SelP-Receptor) family | Cubilin | ↓ | ||
| TC 2 (16) | Electrochemical Potential-driven Transporters | TC 2.A (16) | Porters (uniporters, symporters, antiporters) | TC 2.A.1 (4) | The Major Facilitator Superfamily (MFS) | Solute carrier family 49 member 4 homolog | ↓ |
| TC 2.A.29 (4) | The Mitochondrial Carrier (MC) family | Mitochondrial coenzyme A transporter SLC25A42 | ↑ | ||||
| TC 2.A.7 (3) | The Drug/Metabolite Transporter (DMT) Superfamily | Solute carrier family 35 member F5 | ↓ | ||||
| TC 4 (2) | Group Translocators | TC 4.C (1) | Acyl CoA ligase-coupled transporters | TC 4.C.1 (1) | The Fatty Acid Transporter (FAT) Family | Long-chain fatty acid transport protein 4 | ↓ |
| TC 4.D (1) | Polysaccharide Synthase/Exporters | TC 4.D.1 (1) | The Putative Vectorial Glycosyl Polymerization (VGP) Family | Beta-1,4-mannosyltransferase egh | ↓ | ||
| TC 5 (1) | Transmembrane Electron Carriers | TC 5.B (1) | Transmembrane 1-Electron Transfer Carriers | TC 5.B.2 (1) | The Eukaryotic Cytochrome b561 (Cytb561) Family | Putative ferric-chelate reductase 1 homolog | ↓ |