Table 2.

Lists RCT associated with bruxism and BoNT.

Study	Study Design and Goal	Method	Results
Ondo et al., 2018 [82]	Randomized double-blind placebo-controlled trial Assessed onabotulinum toxinA for bruxism	n = 31 They were given either 200 U of BoNTA (60 and 40 in each masseter and temporalis) or given placebo	Total sleep time and bruxism episodes seemed to favor BoNTA Other than two patients noticing a change in how they smile, no significant side effects were noted
Jadhao et al., 2017 [83]	Randomized placebo-controlled trial Assessed BoNTA for treatment of pain in bruxism	n = 24 Patients were given either bilateral BoNTA or saline or no injections. Each group had eight patients	Pain improved in BoNTA, however, did not change in the other two groups
Shim et al., 2014 [84]	Randomized prospective trial Assessed BoNTA for motor contractions in sleep bruxism	n = 20 One group got 25 U in each masseter (n = 10) while the other group got injection in masseter and temporalis (n = 10)	The masticatory muscle activity frequency was unchanged, but the amplitude was lower Four weeks after injection, nine patients felt reduced teeth grinding and 18 felt reduced morning jaw stiffness
Lee et al., 2010 [85]	Double-blind randomized placebo-controlled trial	n = 12 Six patients received BoNT into each masseter while the other six received saline	Bruxism was lower in patients who received BoNT (p = 0.027)

Abbreviations: BoNT—Botulinum toxin; BoNTA—Botulinum toxin A.