Table 9.

Lists the RCT associated with tics and BoNT.

Study	Study Design and Goal	Sample Size and Method	Results
Marras et al., 2001 [260]	Randomized double-blind placebo-controlled cross-over trial Formulation: onabotulinumtoxinA Assessed if BoNT was useful for simple motor tics	n = 18 Tics involving face, neck, or shoulder were selected for BoNT. Patients were either injected with onabotulinumtoxinA or placebo	Blinking and head turning were the most common tics treated Median proportional change in placebo was +5.8% and BoNT was –39% BoNT helped decrease the premonitory urge and the frequency of tics.

Abbreviation: BoNT—Botulinum toxin.