Table 2.
The cytotoxicity of zeaxanthin-rich extracts 1 and 2, expressed as half inhibitory concentration (IC50, sigmoidal dose-response) and the antiproliferative capacity expressed as significant negative hillslope derived from the linear regression of time-dependent inhibition.
| IC50 Values (μM) | |||||
|---|---|---|---|---|---|
| Cell Line | BJ (CRL-2522) | A375 | |||
| 1 | 24 h | 75.15 ± 0.23 | 62.36 ± 0.08 | ||
| 2 | 24 h | 85.06 ± 11.34 | 92.59 ± 6.71 | ||
| Inhibition of Proliferation | |||||
| Cell line | BJ (CRL-2522) | A375 | |||
| Hillslope | p value | Hillslope | p value | ||
| 1 | 6 h | −4726 ± 905.0 | 0.0002 | 459.6 ± 228.7 | 0.0675 |
| 12 h | −4274 ± 822.5 | 0.0002 | 389.2 ± 301.3 | 0.2208 | |
| 24 h | −2754 ± 606.8 | 0.0007 | −654.8 ± 182.8 | 0.0038 | |
| 2 | 6 h | −4179 ± 877.0 | 0.0005 | −3166 ± 576.8 | 0.0001 |
| 12 h | −3706 ± 807.5 | 0.0006 | −3076 ± 482.9 | <0.0001 | |
| 24 h | −2253 ± 582.5 | 0.0022 | −2109 ± 345.0 | <0.0001 | |