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. 2021 Jan 12;22(2):671. doi: 10.3390/ijms22020671

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of the formation of highly specific transcription hub by OSN enhancers. (A) In progenitor cell, all OR genes are weakly co-expressed. (B) During OSN maturation, transcription of one OR gene is activated randomly, while all others remain completely suppressed. The OR genes are enriched in chromatin marks (H3K9me3, H3K20me3) associated with transcriptional repression. The transcriptionally active OR promoter, labeled H3K4me3, is associated with a hub formed by enhancers enriched in the Edf and Lhx2 proteins and nucleosomes marked by H3K4me1 and H3K27Ac. (C) The LDB1 protein recruited by Lhx2 is involved in the organization of hub formed by OSN enhancers located on different chromosomes. It seems likely that other unknown architectural proteins are involved in hub formation in cooperation with LDB1.