Figure 1.

Co-administration with various chemotherapeutic drugs improves uptake of LuTate in BON-1 and NCI-H727 cells with more cytostatic effect in BON-1 cells. (A) Improved LuTate uptake after chemotherapy. BON-1 and NCI-H727 cells were treated for five days with LuTate alone or with 200 µM TEM, 25 µM 5-FU or 0.5 mg/mL STZ or a combination of 5-FU and STZ. The total cellular uptake of LuTate was measured on the 5th day. (B) A separate set of plates were treated for five days as described for panel A, washed, allowed to recover in fresh medium for 4 days prior to viable cell count, which is presented as fold increase over initial viable count, as indicated by dashed line at 1 on Y-axis. The data derived from two separate experiments, each with a minimum of triplicate independent dishes for each data point are represented as Mean ± SE (n = 6). The Student’s t-test was performed and * indicates significant difference with p value below 0.05.