Table 1.
Encapsulation efficiency and particle size of raw trans-resveratrol and solid dispersion powders produced using the spray drying process.
| Solid Dispersions (Trans-Resveratrol/Polymer Ratio) |
Encapsulation Efficiency a (%) | Volume Mean Particle Size a (μm) |
|---|---|---|
| HPC (25/75) | 97.7 ± 1.5 | 4.84 ± 0.31 (1.89) b |
| HPC (10/90) | 96.9 ± 2.1 | 4.12 ± 0.23 (1.83) |
| HPMC (25/75) | 98.9 ± 1.4 | 5.23 ± 0.31 (1.93) |
| HPMC (10/90) | 98.3 ± 1.1 | 4.98 ± 0.22 (1.81) |
| PVP K30 (25/75) | 99.1 ± 1.0 | 4.03 ± 0.21 (1.71) |
| PVP K30 (10/90) | 98.2 ± 0.9 | 3.98 ± 0.19 (1.65) |
| PVP VA64 (25/75) | 98.6 ± 1.2 | 3.69 ± 0.32 (1.65) |
| PVP VA64 (10/90) | 98.8 ± 1.1 | 3.98 ± 0.19 (1.69) |
| Eudragit E/HCl (25/75) | 98.2 ± 0.8 | 3.76 ± 0.29 (1.53) |
| Eudragit E/HCl (10/90) | 98.0 ± 0.5 | 3.92 ± 0.27 (1.62) |
| Eudragit E/HCl (20/80) | 98.3 ± 0.9 | 3.89 ± 0.15 (1.71) |
| Eudragit E/HCl (15/85) | 98.6 ± 0.6 | 4.01 ± 0.32 (1.65) |
| Raw trans-resveratrol | - | 52.5 ± 1.32 (2.21) |
a Mean ± standard deviation (n = 4). b The span is the width of the distribution and is calculated as follows (d90 − d10)/d50, where d10, d50, and d90 are the diameter sizes at 10%, 50%, and 90% in a cumulative size distribution, respectively.