Figure 5.

Summary of the counteracting effect of GSH on redox imbalance in the salience network. In a healthy state, the excitation–inhibition balance is achieved via the interplay of excitatory and feedback inhibitory neuronal populations. Glutamate-mediated dysconnectivity in psychosis (likely caused by GSH depletion in the developing brain) would manifest in terms of interneuron deficit, leading to excitatory overdrive (i.e., hyperglutamatergic state). The resulting excitatory overdrive can be reduced by increasing inhibition via a compensatory increase in the levels of GSH, at least in a subset of patients. This illustration was produced using biorender.com